The fish in our oceans are filled with drugs, new study says

The fish in our oceans are filled with drugs, new study says

local21news.com

The National Desk | WPEC

WEST PALM BEACH, Fl. (WPEC) — A new study out of South Florida has found the fish in our waters are on drugs.

The fish in our oceans are filled with drugs, new study says

Dozens of pharmaceuticals have been discovered in fish’s blood and tissue.

From valium, blood pressure medicine, to antidepressants all sorts of drugs found in the fish in this study.

The numbers are so alarming scientists say our fisheries could disappear.

“We found pharmaceuticals everywhere and there was no place where basically a fish could be unexposed to pharmaceuticals and that was a surprise,” says Nick Castillo who just completed a three year study with fellow scientists at Florida International University and the Bonefish and Tarpon Trust.

The research team tested the blood of 93 bonefish in South Florida and they found pharmaceutical drugs in every single one.

The average number of drugs reported in just one bonefish was seven and some had up to 16 different prescriptions in their systems.

In Florida bonefish are supposed to be caught and released.

(WPEC)

We don’t eat bonefish but what they eat, other fish are eating too and some of the drugs are altering their behavior.

“So it could be making a fish more bold they’ll take risks they can get eaten more frequently. It can affect their reproduction,” says Castillo.

Dr. Jennifer Rehage, the lead researcher for the study says people are often deceived by the color of the water a fish lives in.

The perception is if the habitat looks nice, the fish are healthy but that’s not always the case.

“Areas that we perceive as pristine and beautiful and the water is clear and turquoise and there’s fish swimming they are contaminated,” says Dr. Rehage.

The pharmaceuticals are being ingested by the fish through human waste.

When we take a prescription, the leftover medicine our body doesn’t process comes out when we go to the bathroom.

From our toilets to waste water treatment plants, Florida has 4,000 of them.

Dr. Rehage says those facilities are outdated and aren’t meant to deal with pharmaceuticals.

“So we don’t have the right equipment and the right legislation, the rules, the treatment and its escalating and it’s exploding right in front of our faces,” she says.

At Florida Atlantic University’s Harbor Branch Oceanographic Institute in Fort Pierce, Dr. James Sullivan says a crisis is just around the corner.

“Plastics pollution, nutrient pollution, harmful algal blooms, ecoli, pharmaceuticals getting into the water, you know how much more can nature take before it becomes a critical turning point that were going to lose very valuable ecosystems in our state,” he says.

The scientists are just starting to research how eating these fish will affect humans.

More studies are expected soon.

https://local21news.com/news/videos/the-fish-in-our-oceans-are-filled-with-drugs-new-study-says-antidepressants-pollution-wastewater-fisheries-water-oceans-valium-blood-pressure-medication

RECALL: Carcinogenic substance in Blood Pressure Meds

Chemical Free Life

Pfizer has issued a recall for three high blood pressure medications:

Accuretic and two generic drugs (quinapril and hydrochlorothiazide tablets and quinapril HCl/hydrochlorothiazide tablets)* are subject to the drug recall.

The drugs are being recalled because they contain elevated levels of nitrosamines**, which pose a cancer risk.

Distributors and wholesalers should stop use and distribution and quarantine the product immediately.

Pfizer recommended that patients taking the medication consult with their doctor about alternative treatment options.

*The medications treat hypertension, which increases the risk for potential dangerous cardiovascular events like strokes.

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**Nitrosamines may be unintentionally introduced when certain chemical reactions are used in the production of medications. Nitrosamines are common in water and foods, including cured and grilled meats, dairy products and vegetables. Everyone is exposed to some level of nitrosamines. These impurities may increase the risk of cancer if people are exposed to them above acceptable…

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Pills sold on Amazon are recalled for containing tadalafil-a drug used to treat erectile dysfunction

NEWS

Some male sexual enhancement pills’ sold on Amazon and other online merchants have been recalled due to the presence of an erectile dysfunction medicine.

In the last few days, the US Food and Medicine Administration (FDA) has issued four-drug recalls.

Tadalafil, an FDA-approved erectile dysfunction medicine, was identified in each of the samples. Despite the fact that the medicine is not permitted for over-the-counter usage, the FDA has issued a recall.

‘The Red Pill,’ ‘Mac Daddy Red,’ ‘Mac Daddy Purple,’ ‘Red Mammoth,’ and ‘MegMan performance booster’ are among the five drugs.

The medicines have since been withdrawn from Amazon, eBay, and Walmart’s online stores. It’s unclear whether there will be any further recalls.

The FDA warns that anyone with diabetes, high blood pressure, or heart disease may be in danger if they use tadalafil without realizing it.

Most people with these problems take blood pressure medications on a daily basis…

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Scientist pleads guilty to stealing trade secrets for Chinese pharma company

local21news.com

Scientist pleads guilty to stealing trade secrets for Chinese pharma company

FILE - This April 28, 2010, file photo shows the GlaxoSmithKline offices in London. (AP Photo/Kirsty Wigglesworth, File)

ZACHARY ROGERS | The National Desk 3 minutes

FILE – This April 28, 2010, file photo shows the GlaxoSmithKline offices in London. (AP Photo/Kirsty Wigglesworth, File)

PHILADELPHIA (TND) — Lucy Xi, 44, has pleaded guilty to stealing trade secrets from GlaxoSmithKline (GSK) for Chinese pharmaceutical company Renopharma.

The Department of Justice says in a news release Xi was employed by GSK at a facility in Upper Merion, Pa. where the company worked on developing biopharmaceutical products that typically cost more than a billion dollars to research and develop.

Xi’s, husband, Yan Mei, established the company Renopharma with financial support from the Chinese government, the DOJ says.

Renopharma was stated to be a company focused on researching and developing anti-cancer drugs, but instead, the DOJ says, it was used as a “repository” of stolen information from GSK.

This defendant illegally stole trade secrets to benefit her husband’s company, which was financed by the Chinese government,” said U.S. Attorney Jennifer Arbittier Williams, who announced Xi’s guilty plea on Monday. “The lifeblood of companies like GSK is its intellectual property, and when that property is stolen and transferred to a foreign country, it threatens thousands of American jobs and jeopardizes the strategic benefits brought about through research and development. Such criminal behavior must be prosecuted to the fullest extent of the law.

The DOJ says Xi sent Mei a document summarizing GSK research on monoclonal antibodies and told him in an email “you need to understand it very well. It will help you in your future business [Renopharma]”.

Mei currently resides in China and is considered to be a fugitive, the DOJ says. Xi, her sister and two other co-defendants have all pleaded guilty for their roles in this crime.

Pharmaceutical firms like GSK invest staggering amounts of time and money to develop new medications and bring them to market,” said Special Agent in Charge of the FBI’s Philadelphia Division Jacqueline Maguire. “When individuals steal valuable trade secrets concerning one of these drugs, it’s a threat both to that firm and beyond. After all, innovation like this propels the U.S. economy. The FBI is committed to enforcing laws that protect the nation’s businesses from such theft. We will not permit American research and development to be scavenged for the benefit of other companies or countries.

https://local21news.com/news/nation-world/scientist-pleads-guilty-to-stealing-trade-secrets-for-chinese-pharma-company-glaxosmithkline-gsk-lucy-xi-china-renopharma-department-justice-pharmacy-medicine-research-development

Horseshoe crab BLOOD in high demand for vaccine and drug testing – and they could go extinct


Conservations warn horseshoe crabs could go to extinct because their blood is being used in Covid vaccines and for drug testing: Up to 30% of the crustaceans have already been killed off in the US

By Stacy Liberatore For Dailymail.com 12:44 EST 17 Dec 2021 , updated 16:42 EST 17 Dec 2021 +7

  • Horseshoe crabs have bright blue blood that is a natural source of Limulus polyphemus
  • This is used to test vaccines, including those for COVID, and drugs for dangerous bacterial toxins before the products hit the market
  • The horseshoe crabs are drained for up to eight minutes and returned to the ocean
  • However, data shows up to 30% of the marine creatures die shortly after 

Horseshoe crabs have been around for 450 million years, surviving mass extinctions and several ice ages, but conservationists say the creatures could soon go extinct because their bright blue blood is vital to pharmaceutical companies.

The blue blood has immune cells, known as Limulus polyphemus (LAL), which are sensitive to toxic bacteria and can be used to test vaccines and drugs for dangerous bacterial toxins before products hit the market. null

The coveted blood has been used for nearly 20 years and has been vital tool in testing the coronavirus vaccines currently on the market.

Scientists drain the horseshoe crabs of their blood and return them to the ocean, after which most of the creatures die – one South Carolina lab says crabs are drained for up to eight minutes. 

‘As it is now, the entire supply chain for endotoxin testing of drugs rests upon the harvest of a vulnerable or near extinct sea creature,’ Kevin Williams, a scientist who manufactures synthetic LAL told The Washington Post.   

Convationists fear the Atlantic horseshoe crabs could go the way of the Asian horseshoe crab that is extinct in Taiwan and disappearing in Hong Kong, as a result of mainly biomedical testing.

While the US horseshoe crab is not currently endangered – they are near threatened – data shows up to 30 percent of the crabs harvested for their blood die when returned to the ocean.

Ryan Phelan, co-founder and Executive Director of Revive and Restore, a wildlife conservation group based in California that lobbied for the synthetic, told Yahoo News: ‘You’ve got a very large, biomedical bleeding industry with a vested interest in keeping those horseshoes crabs coming in and basically protecting this monopoly.’

‘In the US, 525,000 horseshoe crabs per year were captured during 2013 to 2017 and the Atlantic States Marine Fisheries Commission estimates short-term bleeding-induced mortality to be 15 percent (4 percent to 30 percent), resulting in mortality of approximately 78,750 horseshoe crabs annually in recent years comprising a minor portion,’ according to a study published in Frontiers.

The Atlantic Marine Fisheries Commission also estimates that in 2019 US labs extracted blood from 640,000 horseshoe crabs. 

The Atlantic Marine Fisheries Commission also estimates that in 2019 US labs extracted blood from 640,000 horseshoe crabs

The Atlantic Marine Fisheries Commission also estimates that in 2019 US labs extracted blood from 640,000 horseshoe crabs
The coveted blood has been used for nearly 20 years and is being used to test the coronavirus vaccines that are currently on the market. Above is someone pointing at the part where the blood is drawn for use
The coveted blood has been used for nearly 20 years and is being used to test the coronavirus vaccines that are currently on the market. Above is someone pointing at the part where the blood is drawn for use

According to The Verge, horseshoe crab blood has become a $500 billion industry – it can bring as much as $15,000 per quart – and a South Carolina lab that still clings to the old practice is worth $13 billion because of it, The State reports.

Representatives from Charles River previously said that more than 80 million LAL tests are performed each year .

Dr James Cooper, who founded the Charleston facility in 1987, wrote in a company publication last year: ‘The horseshoe crab blood donation is similar to human blood donation.

‘The crabs are bled for a few minutes and returned to sea unharmed.’ 

A Charles River representative told The State: ‘Eight minutes is unofficially recognized as the maximum bleeding time across the industry.’

Scientists drain the horseshoe crabs of their blood and return them to the ocean, after which most of the creatures die - one South Carolina lab says crabs can be drained for up to eight minutes
Scientists drain the horseshoe crabs of their blood and return them to the ocean, after which most of the creatures die – one South Carolina lab says crabs can be drained for up to eight minutes
While the horseshoe crab is not currently endangered, data shows up to 30 percent of the crabs harvested for their blood in the US die when returned to the ocean
While the horseshoe crab is not currently endangered, data shows up to 30 percent of the crabs harvested for their blood in the US die when returned to the ocean

Research conducted at the College of Charleston shows that half of the horseshoe crab’s blood can be drained within those eight minutes and this much harvested can the creatures to move slower when returned to the ocean.

Never mind the stress of being captured, hours spent out of the water and mishandling in the lab – all of which experts say contribute to their deaths. null

A 2011 study conducted by the Department of Natural Resources (DNR), conservation officers responsible for enforcing the environmental and conservation laws and policies, found 20 percent of the crabs died, according to records obtained by The State.  

READ MORE

https://www.dailymail.co.uk/sciencetech/article-10321773/Horseshoe-crab-BLOOD-high-demand-vaccine-drug-testing-extinct.html

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CA apartment building locked down under mandatory quarantine of all residents, with MANDATORY COVID-19 testing

Vaccines to implant tracking devices? Bill Gates goes public

U.S. officials worried about Chinese control of American drug supply

nn_sgo_chinas_hold_on_drug_supply_190912_1920x1080.focal-1000x563nbcnews.com

Ken Dilanian

Antibiotics, which turn life-threatening infections into minor nuisances, are considered the single biggest advance in modern medicine.

But imagine if the supply of antibiotics to the United States was suddenly cut off.

American national security officials are worrying about that scenario as they come to grips with this little understood fact: The vast majority of key ingredients for drugs that many Americans rely on are manufactured abroad, mostly in China.

As the U.S. defense establishment grows increasingly concerned about China’s potentially hostile ambitions, the pharmaceutical supply chain is receiving new scrutiny.

“If China shut the door on exports of medicines and their key ingredients and raw material, U.S. hospitals and military hospitals and clinics would cease to function within months, if not days,” said Rosemary Gibson, author of a book on the subject, “China Rx.”

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Or, Gibson told NBC News, China could potentially “weaponize our medicines. They can sell us medicines without any medicine in them. They can sell medicines that have lethal contaminants in it.”
Prometheus Books

Other generic drugs whose key ingredients are manufactured in China include medicines for blood pressure medicine, Alzheimer’s, Parkinson’s, epilepsy and depression, Gibson says.

 

“We can’t make penicillin anymore,” said Gibson. “The last penicillin plant in the United States closed in 2004.”

 

A Chinese manipulation of drug ingredients or supply may seem like a fairly remote possibility. A state-run Chinese paper said this week that there’s little chance the government would deliberately harm Americans by cutting off the flow of antibiotics.

But as the Trump administration’s trade war with China heats up, a leading Chinese economist gave voice to the worst fears of U.S. policymakers in March, in a speech to an annual national congress.

“China is the world’s largest exporter of vitamins and antibiotic raw materials,” he said, according to an NBC News translation. “Once the export is reduced, the medical systems of some developed countries will not work.”

The Pentagon has noticed.

Workers sort pig intestines in a Chinese factory. A mucous membrane from the intestines is cooked to produce a dry substance known as crude heparin, a first step in producing the drug known as heparin.Qilai Shen / Bloomberg via Getty Images file

“The national security risks of increased Chinese dominance of the global API market cannot be overstated,” Christopher Priest, the acting deputy assistant director for health care operations and Tricare for the Defense Health Agency, told a U.S.-China advisory panel in Washington this summer.

The Defense Health Agency provides health care and prescription drugs to the military.

Priest told the U.S.-China Economic and Security Review Commission that the White House National Security Council is trying to identify medications most at risk if the Chinese decide to use drug supply as a weapon. An NSC spokesman did not respond to a request for comment.

“Basically we’ve outsourced our entire industry to China,” retired Brig. Gen. John Adams told NBC News. “That is a strategic vulnerability.”

Adams, who during a 30-year career served as a military intelligence officer, a military attache in South Korea and deputy U.S. military representative to NATO, added that he believes China understood the implications as it was building a drug ingredients industry.

“I think they know exactly what they’re doing and they’re incredibly good strategists. They’re doing this, they select their industries for the future and they’ve got a plan.”

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Chairwoman Anna Eshoo, D-Calif., conducts a House Energy and Commerce Subcommittee on Health markup on July 11, 2019.Tom Williams / CQ-Roll Call via Getty Images file

Congress is also focusing on the issue. Two leading House Democrats from California, Adam Schiff and Anna Eshoo, warned in a recent op-ed that “If relations decline further, the Chinese government could look for ‘pressure points’ where it can wield outsize leverage or force a change of U.S. policy. Pharmaceutical ingredients could be such a vulnerability: By cutting back their supply or manipulating prices, China could cause pharmaceutical costs to surge. Or worse, we could experience shortages.”

The lawmakers plan to hold hearings soon, they said.

“We should not be held hostage by any foreign country,” Eshoo told NBC News. “We need to move away from any country having a monopoly on the ingredients that we depend upon our antibiotics — anthrax [vaccine], penicillin, high blood pressure drugs.”

Even if China doesn’t restrict supply, there are also questions about the safety of the manufacturing process.

Contaminated supplies of the blood thinning drug Heparin in 2008 led to the deaths of 149 Americans, the government says, prompting the Food and Drug Administration to establish a new policy of stationing inspectors in overseas plants.

But the FDA’s inspection and regulatory regime is widely seen as lax. A congressional investigation in 2016 found that one Chinese company that barred inspectors received only a warning letter, for example.

Last year, the FDA issued an alert over a cancer-causing ingredient used in the blood pressure medication valsartan, made by Chinese company Zhejiang Huahai, resulting in a recall of affected drugs.

Also last year, a scandal over tainted vaccine doses sold in China led to the arrests of executives of Changsheng Biotech, which was also accused of forging data during the production of a rabies vaccine given to infants.

“The FDA is having to make terrible choices between allowing defective medicines on the market and averting drug shortages,” Rosemary Gibson told NBC News.

She argues that the U.S should resume making drug ingredients at home.

“We have a lot of empty manufacturing facilities in the United States, and what it takes is refurbishing those with newer technology that can truly make medicines at up to 40 percent less cost,” she said. “We just need the upfront investment. And it won’t happen unless there is public support and public funding for that.”

https://www.nbcnews.com/news/amp/ncna1052376?__twitter_impression=true