Glimpse into the Regulation of Water Exchange in the Brain

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via Glimpse into the Regulation of Water Exchange in….

March 21, 2015

The human brain is 80 percent water, which makes the constant regulation of the amount of fluid in the brain even more important. Disruptions in the regulation of the direction or speed of the water flow are associated with medical conditions, including hydrocephalus (“water in the brain”), for example. Neurobiologists at Heidelberg University have now discovered a new mechanism that regulates the speed and direction of water flow between the cerebral spinal fluid and the brain cells. This mechanism could also be of great importance in the treatment of hydrocephalic diseases. The research results were published in the “Journal of Biological Chemistry”.

image (Image caption: Isolated ependymal cells show the phosphorylation of AQP4 (in red) after the blocking of GABAA receptors. Cell nuclei are shown in blue. Credit: Universität Heidelberg)

“Both too much and too little…

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